https://www.biotcoklahoma.com/news daily 0.75 2025-11-13 https://www.biotcoklahoma.com/news/qiw0rbhrm0qmoo9iw1010ki9ydmhlo monthly 0.5 2025-11-14 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/67b5d55d-be4a-414b-8a0b-7852d91cd55d/BioTC_08_b.jpg News - BioTC Names Kelley Dowd, Ph.D. Interim Executive Director  - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/1a8503a1-7469-41f3-94c6-7c15d36d81e8/Kelley+%281+of+3%29.jpg News - BioTC Names Kelley Dowd, Ph.D. Interim Executive Director  “I’m honored to step into the role of Interim Executive Director at BioTC and energized by what lies ahead,” said Dr. Dowd. “This is a pivotal moment for the organization as we build on our momentum and expand our impact within Oklahoma’s growing life sciences ecosystem. I’m deeply grateful for the trust placed in me and look forward to working with our partners to accelerate growth, strengthen collaboration, and position BioTC for an even brighter future.” https://www.biotcoklahoma.com/news/biotc-celebrates-completion-of-first-cohort-strengthening-oklahomas-biotech-workforce monthly 0.5 2025-04-15 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/5934b417-94e6-4e86-959a-68ed6fe06f8d/IMG_7855.jpg News - BioTC Celebrates Completion of First Cohort, Strengthening Oklahoma’s Biotech Workforce - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/a2324008-12f4-462b-9373-270427f57871/IMG_7883-2b.jpg News - BioTC Celebrates Completion of First Cohort, Strengthening Oklahoma’s Biotech Workforce - “This program is the future of medicine here in Oklahoma and if you keep pushing forward, it's going to be an amazing career for you.” — Priscilla Aguilar, BioTC Cohort 1 Graduate https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/2c37fd6c-067b-4e8a-8668-4a16dff9fe25/IMG_7906-2.jpg News - BioTC Celebrates Completion of First Cohort, Strengthening Oklahoma’s Biotech Workforce - “If I can do it, you can do it, honestly. I went from being a barista to a full career change.” — Jayson Short, BioTC Cohort 1 Graduate https://www.biotcoklahoma.com/news/biotc-welcomes-new-team-members-and-gains-valuable-insights-at-national-center-for-therapeutics-manufacturingnbsp monthly 0.5 2024-07-30 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/dbe01ef3-2b29-4fc8-bc0f-2ac2587399c5/1721308776167.jpg News - BioTC Welcomes New Team Members and Gains Valuable Insights at National Center for Therapeutics Manufacturing  - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/956c689a-61eb-419c-bd78-1b821127bbc6/1721308777995.jpg News - BioTC Welcomes New Team Members and Gains Valuable Insights at National Center for Therapeutics Manufacturing  - Kacy Unsell, Downstream Purification Specialist and Instructor, added, "The training was incredibly beneficial. I particularly enjoyed learning about the upstream curriculum, such as building a bioreactor and harvesting the product. The hands-on downstream activities provided a clear understanding of TFF systems and chromatography, which will be invaluable in shaping our curriculum." https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/e5a3302d-351c-4478-bffa-5f919fe0c92a/1721308776672.jpg News - BioTC Welcomes New Team Members and Gains Valuable Insights at National Center for Therapeutics Manufacturing  BioTC looks forward to integrating these new insights and techniques into their programs, further advancing their mission to offer high-quality biomanufacturing education and training. https://www.biotcoklahoma.com/news/biotc-oklahoma-announces-new-hires-and-travels-to-inaugural-national-biopharma-workforce-partnership-conference monthly 0.5 2024-07-02 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/6b683c19-eb31-410e-80d4-d9e5a17dcdcb/koey+niimble.jpg News - BioTC Oklahoma Announces New Hires and Travels to Inaugural National BioPharma Workforce Partnership Conference - Make it stand out BioTC Executive Director, Koey Keylon, presenting at NIIMBL https://www.biotcoklahoma.com/news/blog-post-title-one-95zsz monthly 0.5 2023-12-06 https://www.biotcoklahoma.com/biotc-culture daily 0.75 2024-12-09 https://www.biotcoklahoma.com/biotc-culture/optimizing-functionality-within-your-lab-spacenbsp monthly 0.5 2024-09-06 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/87cd7576-d5a2-4cce-9e30-2d8836f6e1d6/Firefly+optimizing+the+functionality+of+your+labspace+62741.jpg BioTC Culture - Optimizing Functionality Within Your Lab Space  - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/26d4da94-7c42-4a03-aa69-d7309af1644b/Newsletter+Circle+templates+%2834%29.png BioTC Culture - Optimizing Functionality Within Your Lab Space  - Make it stand out BioTC Floor Plan https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/dfc8a24e-4cb5-4658-80bf-59d4802471ab/Charles.jpg BioTC Culture - Optimizing Functionality Within Your Lab Space  - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.biotcoklahoma.com/biotc-culture/what-are-cho-cells monthly 0.5 2024-08-29 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/34bc0a92-3cf7-4ec3-a84c-4cf22baf53df/Colorful+Professional+Infographic+Timeline+Poster.png BioTC Culture - What Are CHO Cells?  Chinese hamsters have been used in research since 1919, initially as substitutes for mice in typing pneumococci and later as vectors in Leishmania research, particularly for the study of kala-azar (visceral leishmaniasis). In 1948, the Chinese hamster was first used for breeding in U.S. research laboratories. In 1957, Dr. Theodore T. Puck obtained a female Chinese hamster from Dr. George Yerganian's laboratory at the Boston Cancer Research Foundation and derived the original Chinese hamster ovary (CHO) cell line. The rapid growth of CHO cells in suspension culture and their high protein production capabilities made them a preferred cell line in biomanufacturing. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/161140e3-d47b-4484-b367-ee6dd81c3092/Cho_cells_adherend1.jpg BioTC Culture - What Are CHO Cells?  - CHO cells, taken from the ovary of a Chinese hamster, are a type of epithelial cell, which means they come from the kind of cells that line the surfaces of organs in the body. This makes them tough and versatile, able to grow in different conditions, which is why they're so useful in making medicines. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/4872af54-c556-4c44-822a-4c4d50ac73df/Untitled+design+%289%29.png BioTC Culture - What Are CHO Cells?  - Applications of CHO Cells https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/6d7dbe7b-388a-4a45-b01e-7e62b321d4a7/Expense+Reports+%281%29.png BioTC Culture - What Are CHO Cells?  - Advantages https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/33582864-5bc1-4f67-b028-a564055ecbaf/Expense+Reports.png BioTC Culture - What Are CHO Cells?  - Challenges https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/d7b7c24a-9b2c-402e-8545-8a2bf50c4e61/Firefly+a+cell+on+dna+70538.jpg BioTC Culture - What Are CHO Cells?  - Advancements in biotechnology continue to enhance the utility of CHO cells. Innovations such as CRISPR-Cas9 gene editing, synthetic biology, and improved bioreactor technologies are poised further to increase the efficiency and capability of CHO cells. Researchers are also exploring ways to reduce production costs and improve the scalability of CHO-based manufacturing processes. https://www.biotcoklahoma.com/biotc-culture/continuing-to-combat-brain-drain-oklahomas-burgeoning-bioscience-industrynbspnbspnbspnbsp monthly 0.5 2024-12-09 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/e697aa3b-dea9-4b62-9028-a0e95c4a1b8e/Capture.PNG BioTC Culture - Continuing to Combat Brain Drain: Oklahoma's Burgeoning Bioscience Industry     - Oklahoma's strategic focus on attracting and retaining skilled professionals, coupled with its growing biotech sector, is creating a fertile environment for innovation and economic development. As highlighted in the report "Oklahoma Brain Drain Reversal: What is Happening, and What Can We Learn?" by the Wes Watkins Center for International Trade Development, the recent trend of in-migration and targeted efforts to bolster the local economy are showing promise. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/f1277144-8917-433f-8830-2dc79c61c076/Capture.PNG BioTC Culture - Continuing to Combat Brain Drain: Oklahoma's Burgeoning Bioscience Industry     - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/9d747a47-f682-4173-918d-964c9f3faf0b/Capture.PNG BioTC Culture - Continuing to Combat Brain Drain: Oklahoma's Burgeoning Bioscience Industry     Another critical initiative supporting Oklahoma’s biotech growth is the Oklahoma Center for the Advancement of Science and Technology’s Industry Innovation Program. This program awards funding of up to $500,000 to Oklahoma-based companies leading innovation projects with the potential to create a significant economic impact in Oklahoma. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/acfbe067-09fe-415b-9276-8edf46689627/Innovation+Districtbackground.png BioTC Culture - Continuing to Combat Brain Drain: Oklahoma's Burgeoning Bioscience Industry     - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/b832d1d3-16ca-4f19-8032-557538618146/Koey_Headshot_AnnualBreakfast.2023.jpg BioTC Culture - Continuing to Combat Brain Drain: Oklahoma's Burgeoning Bioscience Industry     Koey Keylon, Executive Director of BioTC, explains, "What Oklahoma City is trying to do is address a couple of things: to get a larger workforce here and to retain local talent by inviting manufacturers to establish operations in Oklahoma." https://www.biotcoklahoma.com/biotc-culture/white-paper-scale-up-and-agitation-scale-up-tip-speed-vs-power-per-volumenbsp monthly 0.5 2024-07-26 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/9fd8e0e8-f56e-453b-9ad1-0284e6ff2d63/Firefly+A+bioreactor+with+an+impeller+inside%2C+with+arrows+illustrating+the+flow+and+mixing+of+gases++%283%29.jpg BioTC Culture - White Paper: Scale-Up and Agitation Scale-Up - Tip Speed vs. Power per Volume  - Scale-up in industrial processes refers to the process of increasing production material from small-scale development to large-scale manufacturing. It involves meticulous attention to factors like agitation, which plays a crucial role in various industries such as pharmaceuticals, chemical processing, and food production. This white paper delves into the significance of agitation scale-up, best practices, common challenges, emerging trends, and potential areas for future research and development in this critical aspect of industrial production. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/f981379f-3e02-491b-8e53-3d3c39e34dc9/image-asset.png BioTC Culture - White Paper: Scale-Up and Agitation Scale-Up - Tip Speed vs. Power per Volume  - Agitation is vital in the production of bioprocesses, particularly in promoting the mass transfer of gases like oxygen that are essential for optimal cell growth and health. In industries like pharmaceuticals, maintaining optimal agitation ensures consistent product quality and yield across different scale sizes. As an upstream specialist at Eli Lilly and Cytovance, understanding agitation's relevance was paramount in achieving desired product specifications without compromising cell viability or health. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/32f8eeb7-50ef-4ad1-8c2a-c2f39ebef2cc/image-asset.png BioTC Culture - White Paper: Scale-Up and Agitation Scale-Up - Tip Speed vs. Power per Volume  - Several strategies exist for scaling up agitation processes while maintaining optimal tip speed and power per volume (P/V) ratios. Constant P/V, Constant Tip Speed, and Constant kLa are commonly used approaches. Constant P/V, in particular, is widely adopted as it ensures the necessary power for appropriate mixing without causing excessive sheer stress on cultures. Calculating P/V involves factors like fluid density, agitation speed, impeller diameter, working volume, and impeller power number, which is determined during process development. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/b17cc4fa-d06f-4f4f-a7a4-e3bd613a745b/image-asset.png BioTC Culture - White Paper: Scale-Up and Agitation Scale-Up - Tip Speed vs. Power per Volume  - Advancements in mixing equipment and computational modeling are shaping the future of agitation scale-up. Micro spargers are preferred over macro spargers to minimize shear stress, while redesigned impeller blades enhance aeration and mixing efficiency. Innovative bioreactor designs like those from Thermo Fisher Scientific offer scalable solutions with advanced mixing technology. Controller software enhancements facilitate seamless scale-up transitions across equipment and production scales. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/a605f4b6-d950-4158-94ee-ffe58e8cf7fc/image-asset.png BioTC Culture - White Paper: Scale-Up and Agitation Scale-Up - Tip Speed vs. Power per Volume  - Future research aims to further improve scale-up methodologies and efficiency, particularly in Cell and Gene Therapy. Automated cell culture platforms and integrated frameworks combining cellular kinetics with computational fluid dynamics show promise in enhancing reproducibility, minimizing product loss, and expediting scale-up processes. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/90ed3e89-0318-477d-a920-42400f0d2d3f/Brandy.jpg BioTC Culture - White Paper: Scale-Up and Agitation Scale-Up - Tip Speed vs. Power per Volume  - About the Author Brandy Kickapoo, a native Oklahoman, brings over 16 years of invaluable experience in the biotechnology industry. She graduated from Marian University in Indianapolis with dual degrees in biology and chemistry. Later, she pursued advanced studies, earning a master's degree in quantitative Analysis and Project Management and Operations from Southern New Hampshire University. Throughout her career, Brandy has excelled in Analytical Development, Process Development, and Quality Control, specializing in ELISA, biological assays, cell culture, and mammalian upstream bioprocesses. Her journey began at Eli Lilly in Indianapolis, and she then made her way back to Oklahoma, contributing significantly to Cytovance Biologics and later Thermo Fisher Scientific. Her favorite tool to use at work is the micropipette. https://www.biotcoklahoma.com/biotc-culture/what-is-okbiostart monthly 0.5 2024-07-18 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/708dccc8-28a2-4eef-adf7-1508b19cf2e1/ENTREPRENEURSHIP+RESOURCE+%282%29.png BioTC Culture - What is OKBioStart?   - OKBioStart, is set to be a cornerstone program within the Oklahoma Biotech Innovation Cluster. They aim to drive the future of healthcare through robust support for life sciences innovators across a ten-county region centered in Oklahoma City. Established to bridge the gap between groundbreaking research and commercial success, OKBioStart aims to transform scientific discoveries into tangible solutions that enhance lives and foster economic growth. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/5c3f58dc-fa32-46d1-9300-2b96298c0e3f/IMG_2633.jpg BioTC Culture - What is OKBioStart?   - OKBioStart is a grant-funded initiative that facilitates collaboration among innovators, founders, and the broader life science community. It focuses on accelerating the translation of innovative concepts into commercially viable technologies in biotech, MedTech, and Virtual Health. The program connects local innovators with a robust ecosystem of support, including academia, corporations, entrepreneurial resources, and government entities. OKBioStart plays a pivotal role in the Oklahoma Biotech Innovation cluster by nurturing early-stage technologies and fostering a supportive ecosystem for biotech startups. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/59c7fda6-e9ab-4da6-8557-37fd13fc51ef/Capture.jpg BioTC Culture - What is OKBioStart?   - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/7cd9bf84-c219-4c6c-a560-88f3b81ed13b/IMG_2672+%281%29.jpg BioTC Culture - What is OKBioStart?   - Professor Charles Rice and team at OKBioConnect Cohort Celebration OKBioStart recently celebrated the success of its inaugural cohort at the VergeOKC, marking a significant milestone in its journey. Looking ahead, applications for the second Concept Program cohort are due on July 19, 2024, with subsequent applications for the Launch Program due on December 2, 2024. These milestones underscore OKBioStart's commitment to fostering innovation and propelling biotech startups in Central Oklahoma. https://www.biotcoklahoma.com/biotc-culture/navigating-the-path-to-market-understanding-the-journey-of-pharmaceutical-drugsnbsp monthly 0.5 2024-07-10 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/c91e5098-f205-48b0-80eb-c8c9c4c3a407/Coming+in+2025+%28Instagram+Post%29.png BioTC Culture - Navigating the Path to Market: Understanding the Journey of Pharmaceutical Drugs  - The journey of a pharmaceutical drug from initial discovery to market availability is a complex and multifaceted process, encompassing scientific research, regulatory approvals, clinical trials, manufacturing, marketing, and post-market surveillance. Understanding this intricate path sheds light on the meticulous steps and rigorous standards that govern the pharmaceutical industry. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/43526473-0dc0-4678-936c-cda266b5a8c2/Firefly+A+photo+of+a+team+of+scientists+working+in+a+modern+laboratory+setting.+wearing+lab+coats%2C+l.jpg BioTC Culture - Navigating the Path to Market: Understanding the Journey of Pharmaceutical Drugs  - The journey begins with drug discovery, where scientists identify potential compounds or biological targets that could lead to therapeutic benefits. This phase involves extensive research, often spanning years of laboratory investigations, computational modeling, and preclinical studies to validate efficacy and safety profiles. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/66244945-2a15-42ee-948a-4b16189cbf47/Firefly+A+photo+of+a+person+sitting+in+a+chair+in+a+clinical+trial+setting.+A+nurse+or+doctor+may+be.jpg BioTC Culture - Navigating the Path to Market: Understanding the Journey of Pharmaceutical Drugs  - Clinical trials are typically divided into three phases, each with distinct objectives and timelines: Phase 1: Lasts several months, involving 20-100 healthy volunteers to assess safety and dosage. Phase 2: Lasts several months to two years, involving several hundred patients to evaluate efficacy and side effects. Phase 3: Lasts one to four years, involving several thousand patients to confirm efficacy, monitor side effects, and compare with commonly used treatments. On average, the entire clinical trial process can take 6-7 years. However, the timelines can vary significantly based on the type of drug, the disease being targeted, and regulatory requirements. https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/5dffd980-3b19-42fb-9de5-37e2b6756904/1227710766.jpg BioTC Culture - Navigating the Path to Market: Understanding the Journey of Pharmaceutical Drugs  - Regulatory Approval Regulatory approval is a critical milestone in the drug development journey. Regulatory agencies, such as the Federal Drug Administration (FDA) in the United States or the European Medicines Agency (EMA) in Europe, review extensive data to assess the drug's safety, efficacy, manufacturing processes, labeling, and risk-benefit profile. The approval process involves: https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/b4824572-01ea-4844-a033-a8b70b6db2c9/salmon-and-red.png BioTC Culture - Navigating the Path to Market: Understanding the Journey of Pharmaceutical Drugs  - The COVID-19 pandemic highlighted the potential for accelerated drug development processes. Normally, clinical trials span multiple years, but the urgency of the pandemic necessitated expedited efforts. Key factors that facilitated the rapid development and approval of COVID-19 vaccines included: https://www.biotcoklahoma.com/events daily 0.75 2025-04-24 https://www.biotcoklahoma.com/events/event-one-2ezmd monthly 0.5 2025-04-24 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/685a31e1-7ca0-409d-9048-b3ac54339768/Fun+INvite.jpg Events - BioTC Open House - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.biotcoklahoma.com/home daily 1.0 2026-03-12 https://www.biotcoklahoma.com/about-biotc daily 0.75 2025-05-14 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/f85ec7f5-574a-4138-972e-4807e5b2d207/BioTC_10_b.jpg About BioTC https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/29ddbfdf-1ca5-456e-8037-c80deb135f4a/BioTC_03_b.jpg About BioTC https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/2181b8e9-e4d1-4af1-afaf-3a7b619a87b0/BioTC_06_b.jpg About BioTC https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/3574c15c-0969-4502-8f6b-810b84583561/BioTC_07_b.jpg About BioTC https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/67b5d55d-be4a-414b-8a0b-7852d91cd55d/BioTC_08_b.jpg About BioTC https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/e0265719-a2b0-4ecd-b931-6836b5bd3eee/BioTC_09_b+%281%29.jpg About BioTC https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/7768ffd0-9d55-438d-94e2-c1238e9394ee/BioTC_01_d.jpg About BioTC https://www.biotcoklahoma.com/biotcoklahomaapply daily 0.75 2025-03-18 https://www.biotcoklahoma.com/biotcoklahoma/jobs/rfps daily 0.75 2024-11-18 https://www.biotcoklahoma.com/team daily 0.75 2025-12-05 https://images.squarespace-cdn.com/content/v1/648ccce635f27773466306b9/8048e741-a441-458b-b308-4f5ad1f2d226/Brandy.jpg 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